Psilocybin Mushrooms for Depression: A Complete Guide

Buy Magic Mushrooms Somerville. The following is for informational purposes only. does NOT advocate the illegal sale, use, or possession of any psychedelics. Be sure to research, understand, and follow all laws and regulations relating to the use and possession of psychedelics in the state or region you live.

Depression is now one of the leading causes of disability in Canada and the rest of the world. With intensive medication and therapy, some people manage to recover. But in up to 30% of cases, depression remains resistant to treatment. If you feel that you’ve run out of options, psilocybin mushrooms might be a good alternative. Here’s what you need to know about mushrooms for depression.

Table of Contents | Buy Magic Mushrooms Somerville

1. What Are Psilocybin Mushrooms?

2. How Mushrooms for Depression Work

3. Are Mushrooms for Depression Effective?

4. Psilocybin-Assisted Therapy

5. What Does A Typical PAT Session Look Like?

6. Microdosing Mushrooms for Depression

7. Pros and Cons of Using Mushrooms for Depression

8. Are Psilocybin Mushrooms for Depression Legal in Canada?

9. The Best Mushrooms for Depression

10. Psilocybin-Assisted Therapy with SRx Health

What Are Psilocybin Mushrooms? | Buy Magic Mushrooms Somerville

Psilocybin mushrooms, or “magic mushrooms,” are species of mushrooms that contain the hallucinogenic compound psilocybin. When ingested, magic mushrooms produce effects similar to LSD. These can include euphoria and altered perceptions.

Recreational use of magic mushrooms dates back to pre-colonial Mesoamerica. For thousands of years, ancient Mayans and Aztecs used mushrooms in rituals. This allowed them to commune with the divine and expand their consciousness.

Today, early studies suggest that magic mushrooms could provide long-term relief from treatment-resistant depression.

Magic mushrooms for depression can be:

  • Eaten raw
  • Ground up and mixed with lemon
  • Boiled into a tea concoction
  • Taken in capsules
  • Crushed into a fine powder and snorted

Euphoric effects usually start within 30 minutes of ingestion and can last six hours.

How Mushrooms for Depression Work | Buy Magic Mushrooms Somerville

According to neuroscientists, depression is associated with disruptions in connectivity between neural networks. A healthy brain communicates and shifts between integrated networks. But the depressed brain is rigid, disconnected, and inflexible.

Neural networks affected in depression are crucial to focus, critical thinking, and goal-directed behaviours. In the depressed brain, these networks are hypoactive and don’t really communicate with each other. At the same time, those involved in introspection and rumination are overactive.

As a result, the depressed brain is trapped in a loop of negative emotions. In other words, people living with depression are stuck in a rut that’s nearly impossible to get out of.

Rewires Brain Circuitry

Ever wondered what it would be like to push a reset button? The closest thing to a reset button we have may very well be psilocybin. Mushrooms for depression exert their effects through the active compound psilocybin.

When ingested, the stomach acids quickly convert psilocybin into its active metabolite, psilocin.
Psilocin is fat-soluble and crosses the blood-brain barrier. Psilocin’s structure mimics the happy hormone serotonin. When it binds to serotonin receptors in the brain, it triggers a cascade of complex changes.

Scientists call these changes “neuronal avalanche.” First, psilocin shuts down the default mode network, which perpetuates negative thought patterns. This allows you to recover your personal and cognitive agencies and promotes active coping.

But perhaps the most profound change is the increase in neural connectivity. According to recent studies, psilocin appears to shake up brain circuitry. This loosens the old, tight, and rigid networks, freeing them up to form new connections.

In a Yale study, a single dose of psilocybin spurred brain cells to form new connections. Not only were these connections larger, but they were stronger and long-lasting as well.

Magic Mushrooms for Depression Dissolve the Ego | Buy Magic Mushrooms Somerville

In some studies, psilocybin has been shown to shut down the part of the brain where the ego lives. The combined effects of interconnectedness and ego dissolution produce the euphoria and transcendence that trippers feel.

However, the experience you will have is deeply personal and unique to you. It can depend on your personality, mental state, and past experiences.

Common features of a psychedelic experience include:

  • Peacefulness
  • Transformative healing
  • Sense of connectedness
  • Increased self-compassion
  • New insights into yourself
  • Sense of meaning
  • Creativity
  • Adaptability
  • Optimism
  • Altered perception

Are Mushrooms for Depression Effective?

Combined with therapy, psilocybin can be effective in treating depression. In fact, early studies show it can be even more helpful than SSRIs. The caveat? We still have a lot more to learn.

It was the landmark Johns Hopkins study that revived interest in mushrooms for depression. In this 2006 study, psilocybin induced powerful sustained mystical experiences in study participants. Participants also reported positive changes in mood, optimism, and openness to social experiences.

Effects Are Rapid and Long-Lasting

Terminally ill cancer patients who received psilocybin experienced reductions in their anxiety and depression. They reported improvements in quality of life, optimism, and spirituality. After six months, 80% continued to show significant improvements in symptoms.

In another cancer study, patients experienced reductions in hopelessness and demoralization. The study also found sustained improvements in quality of life over six months.

A 2021 study found that psilocybin therapy produced long-term improvements in neural flexibility. In a 2020 randomized trial, 67% of participants experienced significant reductions in depression. By week four of therapy, 54% of participants were free from symptoms.

In another study, men and women with depression received two doses of psilocybin. They experienced significant reductions in symptoms for up to 12 months.

Psilocybin-Assisted Therapy | Buy Magic Mushrooms Somerville

Psilocybin-assisted therapy (PAT) is a professionally-guided use of magic mushrooms for depression within a tightly-controlled clinical setting. Unlike the recreational use of magic mushrooms, PAT uses a stringent treatment protocol under the oversight of a licensed psychotherapist.

The main goal behind PAT is to create a supportive space where individuals can begin their transformation through psilocybin. This is in part because, for a first-timer, the experience of ego dissolution can be frightening. A licensed therapist can prepare you and coach you through the experience.

Another advantage to PAT over DIY-ing mushrooms for depression is safety. On your first meeting with a psychotherapist, you will be screened for medical and psychiatric disorders that may put you at risk.

These can include:

  • Hypertension
  • Heart disease
  • Schizophrenia
  • Bipolar disorder
  • Alcoholism

What Does A Typical PAT Session Look Like?

Preparation Session

The therapy begins with three preparatory sessions. During this stage, you and your therapist develop trust and rapport. Your therapist explains the process and prepares you for anything that may come up during your treatment.

Psilocybin Treatment

When you’re sufficiently prepared, you can begin the psilocybin treatment. This phase usually lasts anywhere between six and eight hours. Two guides are in the room with you at all times during your experience.


An integration phase follows each psilocybin session you go through. It’s usually held the morning after your psilocybin treatment. The integration phase helps you make sense of your experience.

Prices vary with each practitioner. It can cost from $2,500 to $5,000.

Microdosing Mushrooms for Depression | Buy Magic Mushrooms Somerville

Microdosing is the process of self-administering magic mushrooms in small enough doses that don’t produce hallucinogenic effects. The standard microdose falls anywhere between 0.1 to 0.9 grams, taken two weeks apart. Anything beyond will take you on a full-blown solo psychedelic trip or put you at risk of developing a tolerance.

You’d think that such a small dose can’t possibly do much. However, according to a 2019 study, microdosers experienced significant improvements in mood and focus. They became more consciously aware and socially open and engaged.

To ensure your safety, purchase your mushrooms for depression in whole dried form from a reputable seller. As an alternative, you can purchase a spore growing kit. This allows you to grow mushrooms for depression in your own home.

*Caution: Don’t drink alcohol with your microdose. Don’t inject mushrooms into your bloodstream, as this can result in a fatal fungal infection.

Pros and Cons of Using Mushrooms for Depression

Mushrooms for depression are generally safe, non-toxic, and non-addictive. Recent studies have established that they produce rapid and enduring effects of up to 12 months.

However, psilocybin mushrooms are not only effective in treating depression. They’re also being used to treat alcoholism, PTSD, and anxiety—with promising results.

The worst thing that can happen when you use mushrooms for depression is unknowingly using the wrong species of mushroom. There are thousands of species of mushrooms out there, and some of them are poisonous. Note that this is only applicable to microdosers.

With PAT, there is a risk of having a bad trip or experiencing temporary side effects like:

  • Loss of focus
  • Panic attacks
  • High blood pressure
  • Nausea
  • Disorientation

Any sale, activity, or possession of magic mushrooms, psilocybin, and psilocin are illegal under USA law. However, mushroom spore kits are sold openly online. The authorities have so far tolerated this.

Fortunately, the landscape is changing for psilocybin mushrooms for depression in USA. In January 2022, Health USA amended the Special Access Program (SAP). Previously, doctors could only request access for patients with end-of-life depression.

With the latest amendment, doctors can now request access to mushrooms for depression for patients who:

  • Have been diagnosed with treatment-resistant depression
  • Have failed previous courses of treatments

The Best Mushrooms for Depression | Buy Magic Mushrooms Somerville

There are over 200 species of mushrooms for depression that contain psilocybin. These are some of the most popular species and strains:

Psilocybe Cubensis

P. cubensis, also called “golden halos,” are the most universally used species of mushrooms for depression. They are widely available and are easy to cultivate. They have long slender stems, concave to flattened tops, and are dark brown in colour. Each gram of dried p. cubensis contains 12 mg of psilocybin.

Psilocybe Baeocystis

Also known as “knobby tops,” this species of psilocybe mushrooms for depression is not for the faint of heart. They contain 15 mg of psilocybin per gram of dried mushroom. Knobby tops are said to produce some of the most intense psychedelic experiences.

B+ Cubensis

B+ cubensis is a strain produced by the crossbreeding of P. cubensis and P. azurescens. With a reputation as a beginner strain, B+ cubensis produces feelings of warmth and ease in users. Its psychedelic effects are a lot more toned down than other mushrooms.

Plus, its ability to reduce nausea and vomiting sets it apart from other mushrooms.

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